Refissa 0.05% is indicated for mitigation (palliation) of fine facial wrinkles, mottled hyperpigmentation and tactile roughness in patients who use a comprehensive skin care and sunlight avoidance program (including sunscreen). Refissa does not eliminate wrinkles, repair sun damaged skin, reverse photo-aging or restore more youthful or younger skin. Do not use if the patient is taking drugs known to be photosensitizers, pregnant, attempting pregnancy, or nursing. Refissa, early in treatment, may cause redness, itching, burning, stinging and peeling. If the degree of irritation warrants, patient should be advised to use less medication and decrease the frequency of application. If still significant, patient should be advised to discontinue use. Please see full Prescribing Information. Refissa is a registered trademark of Spear Pharmaceuticals, Inc. © 2012 Spear Dermatology Products.