Refissa 0.05% is a prescription medicine that may reduce fine facial wrinkles and mottled hyperpigmentation in patients who also protect their skin from the sun and wear sunscreen daily. Refissa does not eliminate wrinkles, repair sun damaged skin or reverse photo-aging. Do not use if you are pregnant, attempting pregnancy, or nursing. Do not use if taking medicines that may increase your sensitivity to sunlight. Use of Refissa may make your skin more likely to burn from sunlight. Refissa, early in treatment, may cause redness, itching, burning, stinging and peeling. If you have questions about side effects, contact your physician. If you are uncomfortable, use less medication and decrease the frequency of application. If discomfort is still significant, discontinue use and consult your physician. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1800-FDA-1088. Please see full Prescribing Information and Patient Package Insert. Refissa is a registered trademark of Spear Pharmaceuticals, Inc. © 2012 Spear Dermatology Products.